Design, Implementation and Evaluation of a Mobile Exhibition Guide

As mobile devices are increasingly merging into our daily lives, exhibition ser- vices are also facing innovation based on the newly available technologies. Our project addresses these new circumstances. We developed a mobile exhibition guide for the exhibition called quot;Mrs Brown's Big Day Out: Hamilton Women in the 1950squot;. That is organized by the Waikato Museum. The proposed sys- tem re-uses the TIP(Tourist Information Provider) system's framework and provides information via mobile devices to visitors on Victoria Street, which is an outdoor part of the exhibition. The information about a sight will be delivered according to visitors' current locations and their interests. We would also like to examine the possibility of re-using our TIP system within the application area of exhibition guide. Therefore, we built the mobile exhibition guide system under the TIP system's framework and developed corresponding services that tailored the system to the requirements of visitors and the exhibition organizer. During the development, we faced a number of challenges, especially, modeling the unknown and unstructured exhibition data into the TIP database. The development process as well as the implementation and evaluation are detailed in this report

Crosstalk between NF-KB and Nucleoli in the Regulation of Cellular Homeostasis:NF- kappaB nucleoli crosstalk in stress response and the regulation of apoptosis

Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis. NF-κB signalling is activated in response to a similar plethora of stresses, which leads to modulation of cell growth and death programs. While nucleolar and NF-κB pathways are distinct, it is increasingly apparent that they converge at multiple levels. Exposure of cells to certain insults causes a specific type of nucleolar stress that is characterised by degradation of the PolI complex component, TIF-IA, and increased nucleolar size. Recent studies have shown that this atypical nucleolar stress lies upstream of cytosolic IκB degradation and NF-κB nuclear translocation. Under these stress conditions, the RelA component of NF-κB accumulates within functionally altered nucleoli to trigger a nucleophosmin dependent, apoptotic pathway. In this review, we will discuss these points of crosstalk and their relevance to anti-tumour mechanism of aspirin and small molecule CDK4 inhibitors. We will also briefly the discuss how crosstalk between nucleoli and NF-κB signalling may be more broadly relevant to the regulation of cellular homeostasis and how it may be exploited for therapeutic purpose

Impact of International Sport Events in Promoting International Attention of Cities：Evidence from Google Trends

In order to raise the international attention and gain more competitive advantages, many Chinese cities are aiming at holding international sport events to promote urban development. However, previous studies indicated that international sport events have attracted international attention for hosting cities, but only stay at theoretical level of interpretation, empirical studies are scarce and needed. Therefore, the major purpose of this study was to investigate the impact of international sport events on urban development from the perspective of cities’ international attention, and to provide new dimensions and ideas for the relationship between sport events and urban development. This study used Google Trends corpus as the data source and used the Google Trends Index to measure five cities’ (Beijing, Shanghai, Nanjing, Chengdu, Wuhan) international attention in order to analyze the impact of international sport events on hosting cities in China. Through data mining, this study collected weekly data of international attention (time range is from January 1st, 2014 to December 31th, 2018) of five cities and compared with major media events in the corresponding period when highest international attention appeared in each city. Using Pearson Correlation, correlation analysis of international attention (all categories) and international attention (sports categories) of five cities was tested. Valuable information was obtained through the relevant keyword search function of the search volume ranking to provide more comprehensive evidence for the empirical results. There was a significant correlation between the international attention (all categories) and international attention (sports categories) in these five cities, and Nanjing\u27s data were the strongest (P=0.987). Through empirical analysis, the peak time of international attention in Beijing, Shanghai, Nanjing, Chengdu and Wuhan in recent five years was highly consistent with the major international sport events (Beijing IAAF World Championships, 2015; ATP1000 Shanghai Masters, 2018; Nanjing Summer Youth Olympics, 2014; ATP250 Chengdu Open ,2018; Wuhan Open ,2018), but the effect was negligible as the events ended. International sport events are an important dynamic attraction for hosting cities to gain more international attention, which can produce intense impulsive impact on each city\u27s international attention. The effect of international sport events on hosting city\u27s international attention is relatively short and concentrated, and there is no obvious long term effect. Finally, the international attention of cities has a relatively stable level from a long time perspective

Data pre-processing for more effective gene clustering

The high-throughput experimental data from the new gene microarray technology has spurred numerous efforts to find effective ways of processing microarray data for revealing real biological relationships among genes. This work proposes an innovative data pre-processing approach to identify noise data in the data sets and eliminate or reduce the impact of the noise data on gene clustering, With the proposed algorithm, the pre-processed data sets make the clustering results stable across clustering algorithms with different similarity metrics, the important information of genes and features is kept, and the clustering quality is improved. The primary evaluation on real microarray data sets has shown the effectiveness of the proposed algorithm.<br /